| Congresso Brasileiro de Microbiologia 2023 | Resumo: 1426-1 | ||||
Resumo:The contribution of distinct animalenvironments to the worsening of the antimicrobial resistanceemergence and disseminationworldwide must be analyzed to establish the conditions for the circulation and maintenance of resistance genes and its transmission to pathogens adapted to the human microbiota. The use of antimicrobials in subtherapeutic doses and for long periods in animal production and the empirical therapy of veterinary infectious diseases practice stand out among the causes of the huge resistance in Veterinary field. It is necessary to understand the connection between people, animals, and the environment in a One Health approach toexpand collaboration and interdisciplinary communication for the establishment of contingency plans to antimicrobial resistance spread control. For the last two decades, the Veterinary Bacteriology Research Group at UFRRJ has been investigating the genetic diversity, virulence, and resistance in bacteria from animal production, maintenance and clinical care environments, and the contribution of these environments for the spread of resistant bacterial clones. The study of the animal environment as conducive to accelerating the evolution of resistance is a critical area for understanding the development of resistance in bacterial pathogens and as a model for the dissemination of resistance genes among circulating bacteria. This lecture addressedour most relevant discoveries in the last decade concerning this subject, among these, the discovery of point mutations that impairs the detection of mecA gene in Staphylococcus aureus from dairy production pointing to the importance of methodological parameters developed for studies in Veterinary Medicine; the detection of the high frequency of occurrence of mcr genes for resistance to colistin in poultry production in the State of Rio de Janeiro, which culminated in studies aimed at detecting these genes in material from wild birds and the unprecedented detection of mcr-9 in an isolate of Panthoeae agglomerans, pointing to the great challenge that climate and environmental changes represent for the control of antimicrobial resistance; and finally, the emergence of previously considered environmental bacterial as pathogens, currently related to infections in humans and animals with important resistance profiles, such as the Acinetobacter calcoaceticus-Acinetobacter baumannii complex. These studies aimed to contribute to the development of integrated approaches focused on reducing selection pressure. Palavras-chave: One Health, Animal Production, Wildlife, Pets Agência de fomento:Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). | |||||